Preheat smoker to 225°F with applewood or pecan chips.
Cook pasta until just under al dente. Drain and set aside.
Make roux: melt butter, whisk in flour, cook 2 min.
Add milk and cream slowly, whisk until thickened (5 min).
Melt in cream cheese, then cheddar and gouda in batches.
Season with garlic powder, onion powder, mustard, paprika, salt, pepper.
Fold in pasta. Transfer to cast iron skillet.
Mix panko with melted butter and parmesan; sprinkle on top.
Smoke uncovered at 225°F for 60–90 minutes until golden.
Rest 5–10 minutes before serving.